The reference site for Tegaserod

Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation.

WHAT IS Tegaserod?

Tegaserod is used to treat severe, chronic, irritable bowel syndrome (IBS) in women who have constipation as their main bowel problem (constipation-predominant). It is also used to treat chronic idiopathic constipation in patients less than 65 years of age. However, this medication has not been shown to be helpful for men with irritable bowel syndrome.

Tegaserod works by increasing the action of serotonin (a body chemical) in the intestines, which speeds up the movement of stools (bowel movements) through the bowels.

It is currently marketed by Novartis under the trade names Zelnorm® in the US or Zelmac® in other countries.

Brand Name(s): Zelnorm; Zelmac
CAS nº: 189188-57-6
(the GAH seh rod)

 

Product Info

The sections below will provide you with more specific information and guidelines related to tegaserod and its correct use. Please read them carefully.

FDA Information

Tegaserod was approved by the US Food and Drug Administration in July, 2002.

A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Tegaserod is used to treat severe, chronic, irritable bowel syndrome (IBS) in women who have constipation as their main bowel problem (constipation-predominant). It is also used to treat chronic idiopathic constipation in patients less than 65 years of age.

However, this medication has not been shown to be helpful for men with irritable bowel syndrome.

Tegaserod increases the action of serotonin (a body chemical) in the intestines. This speeds the movement of stools (bowel movements) through the bowels.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Tegaserod comes as a tablet to be taken orally.

Take tegaserod exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Tegaserod should be taken twice a day on an empty stomach shortly before you eat a meal or as your doctor prescribes it. Take each dose with a full glass of water.

Please note that this medication does not improve the symptoms of IBS for everyone. When tegaserod is beneficial, it helps to reduce pain and discomfort in the abdominal area, bloating, and constipation. Some or all symptoms may improve within one to two weeks. If you do not see any improvement in your symptoms after 4 to 6 weeks, talk to your doctor.

Tegaserod is not a cure for irritable bowel syndrome. If you stop taking tegaserod, symptoms may return within 1 or 2 weeks, so it is important to take tegaserod regularly to get the most benefit.

What special precautions should I follow?

BEFORE TAKING TEGASEROD:

Tell your doctor if you have any of the following: diarrhea or if diarrhea is your main symptom of IBS; gallbladder problems; a bowel obstruction, abdominal adhesions, sphincter of Oddi dysfunction; kidney disease; or liver disease. You may not be able to take tegaserod, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Some drugs may interact with tegaserod. Talk your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Stop taking tegaserod and contact your doctor if you experience new or increased stomach pain or blood in your stool.

Diarrhea is an occasional side effect of tegaserod. Most often, diarrhea has been reported during the first week of starting tegaserod. Typically, diarrhea diminishes with continued therapy. If severe diarrhea, or diarrhea together with bad cramping, abdominal pain, lightheadedness, fainting, or dizziness develops, stop taking tegaserod and contact your doctor.

Tegaserod is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take tegaserod without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether tegaserod passes into breast milk. Do not take tegaserod without first talking to your doctor if you are breast-feeding a baby.

IMPORTANT NOTE: Tegaserod has not been shown to be helpful for men with irritable bowel syndrome.

What should I do if I forget a dose?

If you miss a dose, skip the missed dose and take only the next regularly scheduled dose.

Do not take a double dose of this medication.

What side effects can this medication cause?

If you experience an allergic reaction (such as difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives) to tegaserod, stop taking this medication and seek emergency medical attention.

Moreover, stop taking tegaserod and contact your doctor if you experience new or increased stomach pain or blood in your stool.

Diarrhea is an occasional side effect of tegaserod. Most often, diarrhea has been reported during the first week of starting tegaserod. Typically, diarrhea diminishes with continued therapy. If severe diarrhea, or diarrhea together with bad cramping, abdominal pain, lightheadedness, fainting, or dizziness develops, stop taking tegaserod and contact your doctor.

In studies, patients receiving tegaserod had more abdominal surgery than patients receiving sugar pills. However, it is not known if tegaserod will increase the risk of abdominal surgery. If you suddenly get different or worse abdominal pain, contact your doctor.

Other less serious side effects may be more likely to occur. Continue to take tegaserod and talk to your doctor if you experience:

headache, dizziness or migraine
back pain or joint pain
abdominal pain, nausea or flatulence (gas)

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911.

Symptoms of a tegaserod overdose may include:

diarrhea
headache
abdominal pain
flatulence
nausea
vomiting

Product Images

PICTURES OF TEGASEROD PILLS

Below you will find images and specific information on the principal types of tegaserod that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: ZELNORM®
Strength(s): 6 MG
Imprint: NVR EH
Manufacturer: NOVARTIS

Name: ZELMAC®
Strength(s): 6 MG
Imprint: Zelmac 6
Manufacturer: NOVARTIS

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